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TAU Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 10274-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16876553

  • 1236.20 SEK / 20µL
Estimated Shipment: 08-12-2021

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Description

Description

MAPT antibody was produced by immunizing animals with N-terminal of MAPT and can detect approx. 70 kDa and 100 kDa bands in brain tissues.

Tau is a neuronal microtubule-associated protein found predomitly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer′s diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick′s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Specifications

Specifications

TAU
0.23 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P10636, P10637, P19332
DDPAC, FTDP 17, MAPT, MAPTL, MSTD, MTBT1, MTBT2, Neurofibrillary tangle protein, Paired helical filament tau, PHF tau, PPND, TAU
Rabbit
IgG
20 μL
-20°C
Primary
17762, 29477, 4137
Immunofluorescence, Western Blot, Immunohistochemistry (Paraffin), Immunocytochemistry
Unconjugated
MAPT
Liquid
Mapt
TAU Fusion Protein Ag0354
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Mouse, Human, Rat
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