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Tocris Bioscience™ TCH-165
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Produktkod. 18765466
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Produktkod. Kvantitet
18765466 10 mg
18746176 50 mg
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Produktkod. 18765466 Leverantör Tocris Bioscience™ Leverantörsnummer 7489/10

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Beskrivning

Enhancer of 20S proteasome assembly and 20S-mediated protein degradation

TCH-165 is an enhancer of 20S proteasome assembly. TCH-165 regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation. TCH-165 enhances the proteolytic activity of the 20S proteasome by increasing substrate accessibility to the 20S catalytic chamber through 20S gate opening. TCH-165 enhances 20S-mediated degradation of IDPs, α-syn, and tau in vitro, and does not induce the degradation of structured proteins such as GAPDH. TCH-165 enhances c-MYC degradation by the 20S proteasome, which reduces c-MYC levels in vivo, and is effective in bortezomib (Cat. No. 7282) resistant cells. TCH-165 down-regulates c-MYC target genes and inhibits cancer cell proliferation and tumor growth in vivo.
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Specifikationer

Kemiskt namn eller material Ethyl (4 R,5 R)-rel-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1 H-imidazole-4-carboxylate
CAS 1446350-60-2
Kvantitet 10 mg
Mål Proteasome Modulators
Molekylformel C39H37N3O3
Renhet 0.98
Produkttitel
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