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Invitrogen™ TCP1 Monoclonal Antibody (91a), FITC
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Produktkod. 17857302
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Kvantitet:
100 μg
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Produktkod. Kvantitet
17857302 100 μg
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Produktkod. 17857302 Leverantör Invitrogen™ Leverantörsnummer MA545719

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Beskrivning

Rat Monoclonal Antibody

1 μg/mL of MA5-45719 was sufficient for detection of TCP1 alpha in 20 μg of 3T3 cell lysate by colorimetric immunoblot analysis using Goat anti-rat IgG:HRP as the secondary antibody. Detects approximately 60kDa. Also detects approximately 92kDa. Cross reactivity with human HSP60 has been observed with this antibody in immunoblot analysis. Reacts weakly with Saccharomyces cerevisiae, consistent with the epitope sequence being AKLRS (instead of AKLRA). In C. elegans, it reacts with TCP1 alpha and another CCT subunit. In plants, it recognizes TCP1 of Pisum sativum, and the sequence of Arabidopsis thalania TCP1 over the region of the epitope AKLRA. It has also been shown that it reacts with a subunit of a specialized chaperonin which folds phytochrome.

The T Complex Polypeptide 1 (TCP-1) is approximately 60 kDa protein constitutively expressed in almost all eukaryotic cells, and is upregulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin. The family of proteins termed chaperonins act to recognize and stabilize polypeptide intermediates during folding, assembly and disassembly, and share many characteristics with Heat Shock Protein 70 (HSP70) including high abundance, induction by environmental stress, and ATPase activity. The chaperonin family includes the mitochondrial HSP60, Escherichia coli GroEL, the plastid Rubisco-subunit binding protein, and the archaebacterial protein TF55. The TCP-1 sequence shows nearly 40% identity to TF55, but only minimal similarity to HSP60 and GroEL.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen TCP1
Användningsområden Flow Cytometry, Immunoprecipitation, Western Blot, Immunocytochemistry
Klassificering Monoclonal
Klona 91a
Koncentration 1 mg/mL
Konjugera FITC
Formulering PBS, 9.09mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative; pH 7.4
Gen TCP1
Genaccessionsnr. P11983, P12612, P17987, P18279, P28480, Q32L40
Gene Alias 65 kDa antigen; AI528772; c-cpn; CCT; Cct1; Ccta; CCTalpha; CCT-alpha; chaperonin-containing T-complex alpha subunit TCP1; chaperonin-containing T-complex polypeptide alpha subunit; cytosolic chaperonin containing t-complex polypeptide 1; D6S230E; hypothetical protein; p63; tailless complex polypeptide 1; tailless complex polypeptide 1A; Tailless complex polypeptide 1B; t-complex 1; t-complex polypeptide 1; t-complex protein 1; T-complex protein 1 alpha subunit-like protein; T-complex protein 1 subunit alpha; T-complex protein 1 subunit alpha A; T-complex protein 1 subunit alpha B; T-complex protein 1, alpha subunit; Tcp1; Tcp-1; TCP-1-A; TCP-1-alpha; TCP-1-B; Tp63; TRic; Unknown (protein for MGC:133746); YD8142.13; YD8142B.04; YDR212W
Gensymboler TCP1
Värd art Rat
Immunogen Recombinant Mouse TCP1 alpha protein fragment (carboxy terminal region).
Reningsmetod Protein G
Kvantitet 100 μg
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 100153485, 100302435, 100689476, 100713821, 21454, 24818, 484064, 512043, 6950, 851798
Målarter Human, Mouse, Rat, Canine, Rabbit, Monkey, Bovine, Hamster, Pig, Drosophila, Yeast, Yeast, C. elegans
Innehåll och lagring 4°C, store in dark
Produkttyp Antibody
Form Liquid
Isotyp IgG2a
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