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TET2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 21207-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16840835

  • 3313.85 SEK / 150µL
Estimated Shipment: 03-10-2022
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Description

Description

This antibody recognizes all three isoforms of TET2.

TET2 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydromethylcytosine (5hmC) and plays a key role in active DNA demethylation. TET2 has a preference for 5-hydroxymethylcytosine in CpG motifs. It mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC) and conversion of 5fC to 5-carboyxlcytosine (5caC). Conversion of 5mC into 5hmC, 5fC, and 5caC probably constitutes the first step in cytonsine demethylation. In addition to TET2′s role in DNA demethylation, it is also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Mutations in the genes can result in Polycythemia vera and Myelodysplastic syndrome.
Specifications

Specifications

TET2
Polyclonal
Unconjugated
TET2
KIAA1546, tet oncogene family member 2, TET2
Rabbit
Antigen Affinity Chromatography
RUO
214133, 54790
-20°C
Liquid
Western Blot, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence, Immunocytochemistry
0.4 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q4JK59, Q6N021
TET2
TET2 Fusion Protein Ag15583
150 μL
Primary
Mouse, Human
Antibody
IgG
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