missing translation for 'onlineSavingsMsg'
Läs mer
  1. Home
  2. Products
  3. Proteinanalysreagenser
  4. Bioaktiva små molekyler
  5. STEMCELL Technologies TG101348

STEMCELL Technologies TG101348

Produktkod. 17120232
Encompass_Preferred
Change view
Klicka för att se tillgängliga alternativ
Kvantitet:
1 mg
10 mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Produktkod. Kvantitet
17120232 10 mg
17110232 1 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
Denna artikel kan inte returneras. Se returpolicy
Produktkod. 17120232 Leverantör STEMCELL Technologies Leverantörsnummer 73474

Please to purchase this item. Need a web account? Register with us today!

Denna artikel kan inte returneras. Se returpolicy

Beskrivning

JAK/STAT pathway inhibitor; Inhibits JAK2

  • TG101348 is an inhibitor of Janus kinase 2 (JAK2) with an IC50 of 6 nM
  • It also inhibits related kinases fms-related tyrosine kinase 3 (FLT3), RET, and JAK3 with less potent activity, having IC50 values of 25, 17 and 169 nM, respectively (Pardanani et al.) It is proposed to bind to the ATP binding pocket of its kinase targets (Zhou et al.)
  • Inhibits growth of Ba/F3 cells expressing JAK2 V617F or MPL W515L mutations (Pardanani et al.)
  • Reduces tumor cell burden and increases survival in mouse models of JAK2 V617F-induced hematopoietic and myeloproliferative disease (Pardanani et al.; Wernig et al.)
  • Sensitizes erlotinib-resistant non-small cell lung cancer cells to erlotinib treatment in vitro and in a mouse xenograft model (Zhang et al.)
  • Displaces BRD4 from chromatin and suppresses c-MYC expression in multiple myeloma cells in vitro (Ciceri et al.)

Specifikationer

CAS 936091-26-8
Synonym Fedratinib; SAR302503
Kvantitet 10 mg
Molekylformel C27H36N6O3S
Renhet ≥98%
Produkttitel
Välj ett problem

Genom att klicka på Skicka bekräftar du att du kan bli kontaktad av Fisher Scientific angående feedbacken du har lämnat i detta formulär. Vi kommer inte att dela din information för andra ändamål. All kontaktinformation som tillhandahålls ska också underhållas i enlighet med vår Sekretesspolicy.