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Human G-CSF, Recombinant Protein, Invitrogen™

Recombinant Protein

Brand:  Invitrogen RP75570

Additional Details : CAS Number : 69-74-9 Weight : 0.01000kg

Product Code. 11598891

  • 5540.00 SEK / 100µg
Estimated Shipment: 11-02-2022

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Description

Description

GCSF (human) Recombinant Protein, RP-75570, from Invitrogen.

G-CSF (Granulocyte colony stimulating factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes. Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been described. The pleotropic cytokine is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts and bone marrow cells. G-CSF has been shown to have specific effects on the proliferation, differentiation and activation of hematopoietic cells. G-CSF is also expressed by various transformed cells such as carcinoma cells and myeloblastic leukemia cells. G-CSF is encoded by two distinct DNA sequences, resulting in a full size, high activity and a shorter, low activity isoform of G-CSF. G-CSF is highly conserved among species and has been shown to exert its biological functions through interaction with its receptor expressed on the surface of hematopoietic progenitors, neutrophilic granulocytes and certain carcinoma cell lines. Clinical use of G-CSF has been approved for several therapeutic applications, treatment of neonatal infections, therapy of acute myocardial infarction, granulocyte transfusion in patients with neutropenia, in severe infections and sepsis, therapy in chronic autoimmune neutropenia, treatment of acute myeloid leukemias, Sweet′s syndrome and AIDS. Further, G-CSF has been shown to be a marker protein for different carcinomas such as bladder cancer and dysfunction of the protein has been linked to Kostmann Syndrome. This product contains purified recombinant human GCSF protein with an N-terminal hexahistidine tag. This product may be used as a positive control in many immunological assays. This protein has a molecular weight of ∽23.19 kDa.
Specifications

Specifications

P09919
Control, Western Blot
Control, Western Blot
20mM tris HCl with 50% glycerol and no preservative; pH 8.0
23.19
8.0
100μg
-20°C, Avoid Freeze/Thaw Cycles
Granulocyte Colony Stimulating Factor
CSF3
Unlabeled
E. coli
Recombinant
0.8mg/mL
Liquid
1440
Human G-CSF
purified
E. coli
RUO
Human G-CSF
Human
Hu
Recombinant
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