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Invitrogen™ Rat IL-17A Recombinant Protein

Recombinant Protein

Brand:  Invitrogen™ RP8621

Additional Details : Weight : 0.01000kg

Product Code. 11529141

  • 3840.00 SEK / 25µg
Estimated Shipment: 16-04-2024
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Description

Description

IL-17A (rat) Recombinant Protein, RP-8621, from Invitrogen.

Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. IL-17A is a 32 kDa long, disulfide-linked homodimer consisting of 136 amino acids that is a member of a six-species family of proteins (IL-17A-17F) and signals through the IL-17 receptor (IL-17R/CDw217). High levels of IL-17A homodimer are produced by activated peripheral blood CD4+ T-cells, and IL-17A also enhances expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts. In particular, human IL-17A also stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In the presence of human IL-17A, fibroblasts can sustain the proliferation of CD34+ hematopoietic progenitors and induce maturation into neutrophils. Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse receptor. IL-17A regulates the activities of NF-kappa B and mitogen-activated protein kinases, stimulates the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), and enhances the production of nitric oxide (NO). Recombinant rat IL-17A is a non-glycosylated, disulfide-joined homodimer, having a total molecular weight of 30 kDa. Purity is typically greater than 97% and endotoxin level less than 1 EU/ug. The expected biological activity (ED50) is determined by the dose-dependent induction of IL-6 production in cultured mouse NIH-3T3 fibroblasts and is typically 1-2ng/mL. The specific activity of this protein is 1x10^6 units/mg. Reconstitute using sterile water at 0.1mg/mL and centrifuge prior to opening vial. Gently pipet solution down the sides of the vial. DO NOT VORTEX sample. Store reconstituted material at -20°C and add 0.1% BSA for additional stability. Amino acid sequence: MAVLIPQSSV CPNAEANNFL QNVKVNLKVL NSLSSKASSR RPSDYLNRST SPWTLSRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPEKCPF TFRVEKMLVG VGCTCVSSIV RHAS.
Specifications

Specifications

Q61453
Control
301289
Rat IL-17A
25μg
-20°C, Avoid Freeze/Thaw Cycles
R-IL-17-A
Il17a
Unconjugated
E. coli
Lyophilized
purified
0.1mg/mL
0.01M citric acid with no preservative; pH 3.0
∽30
3.0
E. coli
RUO
Rat IL-17A
Rat
Rt
Recombinant
Recombinant
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in vitro research only.