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Tocris Bioscience™ Thiazovivin
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Produktkod. 18045212
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Kvantitet:
10 mg
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Produktkod. Kvantitet
18045212 10 mg
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Produktkod. 18045212 Leverantör Tocris Bioscience™ Leverantörsnummer 3845/10

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Beskrivning

ROCK inhibitor ; improves the efficiency of fibroblast reprogramming and induction of iPSCs

Thiazovivin is a selective, cell-permeable Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor (IC50 = 0.5 μM). Thiazovivin enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614) and PD 0325901 (Cat. No. 4192). Thiazovivin improves the survival of human embryonic stem cells (hESCs) upon trypsinization and increases cell adhesion through the regulation of E-cadherin and significantly improves direct reprogramming efficiency. In combination with Valproic acid, sodium salt (Cat. No. 2815), Purmorphamine (Cat. No. 4551) and A 83-01 (Cat. No. 2939), Thiazovivin can be used to directly reprogram mouse embryonic fibroblasts into chemically induced neural stem cells.
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Specifikationer

Kemiskt namn eller material Thiazovivin
CAS 1226056-71-8
Kvantitet 10 mg
Molekylformel C15H13N5OS
Formel vikt 311.36
Renhet 98%
Molekylvikt (g/mol) 311.363
Produkttitel
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