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Thioredoxin Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 14999-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16823964

  • 1236.20 SEK / 20µL
Estimated Shipment: 07-12-2021

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Description

Description

Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cystein residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53 , NF-kB and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
Specifications

Specifications

Thioredoxin
0.42 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P10599, P10639, P11232
ADF, ATL derived factor, SASP, Thioredoxin, TRDX, TRX, TRX1, TXN
Rabbit
IgG
20 μL
-20°C
Primary
116484, 22166, 7295
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunofluorescence, Flow Cytometry, Immunoprecipitation
Unconjugated
TXN
Liquid
TXN
Thioredoxin Fusion Protein Ag6989
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Mouse, Human, Rat
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