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Tocris Bioscience™ TL 13-112
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Produktkod. 18755546
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Kvantitet:
5 mg
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18755546 5 mg
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Produktkod. 18755546 Leverantör Tocris Bioscience™ Leverantörsnummer 6745/5

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Beskrivning

Selective ALK Degrader (PROTAC™)

Selective anaplastic lymphoma kinase (ALK) degrader (DC50 values are 10 and 40 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302) conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Maximum degradation exhibited at 16 h.

Negative control TL 13-110 (Cat. No. 6746) also available.

TL 13-112 is a selective anaplastic lymphoma kinase (ALK) Degrader (PROTAC®) (DC50 values are 10 and 40 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302) conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Maximum degradation exhibited at 16 h.

Negative control TL 13-110 (Cat. No. 6746) also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

TRUSTED_SUSTAINABILITY

Specifikationer

Kemiskt namn eller material N-[2-[2-[2-[4-[4-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methylethoxy)phenyl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetamide
CAS 2229037-19-6
Kvantitet 5 mg
Molekylformel C49H60ClN9O10S
Formel vikt 1002.57
Renhet 98%
Produkttitel
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