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Tocris Bioscience™ TMI 1, >98%
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Produktkod. 30000874
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30000874 10 mg
30000996 50 mg
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Produktkod. 30000874 Leverantör Tocris Bioscience™ Leverantörsnummer 5960/10

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Beskrivning

Adam 17 (TACE) and MMP inhibitor; orally bioavailable

Adam 17 (TACE) and MMP inhibitor (IC50 values are 3, 4.7, 6.6, 8.4, 12, 26 and 26 nM for MMP-13, MMP-2, MMP-1, ADAM 17, MMP-9, MMP-7 and MMP-14, respectively). Suppresses TNF-α production in an acute LPS-mouse model. Reduces severity score in an in vivo model of rheumatoid arthritis. Displays selective cytotoxicity to tumor cells and cancer stem cells in vitro. Induces tumor apoptosis in a breast cancer in vivo model. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Kemiska identifierare

CAS 287403-39-8
Molekylformel C17H22N2O5S2

Specifikationer

Kemiskt namn eller material (3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide
Kvantitet 10 mg
Löslighet Soluble to 100mM in DMSO and to 20mM in ethanol
Formel vikt 398.49
Renhet >98%
Molekylvikt (g/mol) 398.492
Produkttitel
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