TOX, clone: TXRX10, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 14-6502-80
Additional Details : Weight : 0.01000kg
DescriptionDescription: This TXRX10 monoclonal antibody reacts with human and mouse TOX, which is also known as Thymocyte selection-associated HMG box protein. This DNA-binding nuclear factor is expressed in thymocytes, T lymphocytes, NK cells, and lymphoid tissue-inducer (LTi) cells. TOX expression in thymocytes is upregulated during beta-selection and positive selection. Studies using Tox knockout mice have demonstrated a critical role for TOX in CD4^+ T cell development as a regulator of the CD4^loCD8^lo to CD4^+CD8^lo transition. Moreover, TOX has been shown to be involved in the development of NK and LTi cells. While its regulation remains unclear, TOX expression has been shown to be induced by calcineurin-mediated TCR signaling in thymocytes during positive selection.Applications Reported: This TXRX10 antibody has been reported for use in immunoprecipitation and immunoblotting (WB).Applications Tested: This TXRX10 antibody has been tested by immunoblotting of reduced cell lysate prepared from mouse thymocytes at less than or equal to 5 ug/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
|PBS with 0.09% sodium azide; pH 7.2|
|TOX1, thymocyte selection-associated high mobility group box protein TOX, thymus high mobility group box protein TOX|
|Immunoprecipitation, Western Blot|
|IgG2a, kappa, kappa|
|Store at 2-8°C.|
For Research Use Only.