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TOX, clone: TXRX10, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-6502-82

Additional Details : Weight : 0.01000kg

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Product Code. 15247717

  • 1514.00 SEK / 100µg


Estimated Shipment date
from Supplier 25-09-2018
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Description

Description

Description: This TXRX10 monoclonal antibody reacts with human and mouse TOX, which is also known as Thymocyte selection-associated HMG box protein. This DNA-binding nuclear factor is expressed in thymocytes, T lymphocytes, NK cells, and lymphoid tissue-inducer (LTi) cells. TOX expression in thymocytes is upregulated during beta-selection and positive selection. Studies using Tox knockout mice have demonstrated a critical role for TOX in CD4^+ T cell development as a regulator of the CD4^loCD8^lo to CD4^+CD8^lo transition. Moreover, TOX has been shown to be involved in the development of NK and LTi cells. While its regulation remains unclear, TOX expression has been shown to be induced by calcineurin-mediated TCR signaling in thymocytes during positive selection.Applications Reported: This TXRX10 antibody has been reported for use in immunoprecipitation and immunoblotting (WB).Applications Tested: This TXRX10 antibody has been tested by immunoblotting of reduced cell lysate prepared from mouse thymocytes at less than or equal to 5 ug/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

TOX
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q66JW3, O94900
TOX1, thymocyte selection-associated high mobility group box protein TOX, thymus high mobility group box protein TOX
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Murine
ImmunoprecipitationþWestern Blot
TXRX10
Unconjugated
TOX
Purified
Tox
IgG2a, kappa
100μg
Store at 2-8°C.
Primary
9760
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