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Invitrogen™ Transferrin Receptor Monoclonal Antibody (MEM-189)
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Produktkod. 11574592
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Kvantitet:
100 μg
Förpackningsstorlek:
100µg
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Produktkod. 11574592 Leverantör Invitrogen™ Leverantörsnummer MA119299

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Beskrivning

Mouse Monoclonal Antibody

This antibody reacts with an extracellular epitope on CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. The antibody MEM-189 does not block binding of transferrin to the receptor. Western blot should be performed under non-reducing conditions.

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
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Specifikationer

Antigen Transferrin Receptor
Användningsområden Flow Cytometry, Immunoprecipitation, Western Blot, Immunocytochemistry
Klassificering Monoclonal
Klona MEM-189
Koncentration 1 mg/mL
Konjugera Unconjugated
Formulering TBS with 15mM sodium azide; pH 8
Gen TFRC
Genaccessionsnr. P02786
Gene Alias 2610028K12Rik; AI195355; AI426448; AU015758; CD antigen CD71; CD71; chicken transferrin receptor; E430033M20Rik; I79_000642; IMD46; mammary tumor virus receptor 1; Mtvr1; Mtvr-1; p90; sTfR; T9; TfR; tfR1; TFR2; TFRC; TR; transferrin receptor; transferrin receptor (p90, CD71); transferrin receptor 2; transferrin receptor protein 1; Transferrin receptor protein 1, serum form; Trfr
Gensymboler TFRC
Värd art Mouse
Immunogen KG1 human acute myelogenous leukaemia cell line.
Reningsmetod Protein A
Kvantitet 100 μg
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 7037
Målarter Human
Innehåll och lagring 4°C, do not freeze
Produkttyp Antibody
Form Liquid
Isotyp IgG1
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