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Transglutaminase 2/TGM2 Antibody (TGM2/419), R&D Systems™

Produktkod. 18600856 Handla allt Bio Techne Produkter
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Produktkod. 18600856 Leverantör Novus Biologicals Leverantörsnummer NBP2445940.1mg
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    4553.85 SEK / 0.1mg
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Beräknad leverans: 26-11-2026
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Beskrivning

A Novus product, part of R&D Systems. Mouse Monoclonal Antibody

Transglutaminase 2/TGM2 Monoclonal specifically detects Transglutaminase 2/TGM2 in Human, Monkey, Mouse, Rabbit, Rat samples. It is validated for Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen Transglutaminase 2/TGM2
Användningsområden Immunohistochemistry, Western Blot
Klassificering Monoclonal
Klona TGM2/419
Koncentration 0.2mg/mL
Konjugera Unconjugated
Utspädning Flow Cytometry 0.5 - 1 ug/million cells in 0.1 ml, Immunohistochemistry-Paraffin 0.5 - 1.0 ug/ml, SDS-Page, Immunofluorescence 0.5 - 1.0 ug/ml
Formulering 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Genaccessionsnr. P21980
Gene Alias C polypeptide, EC 2.3.2.13, G-ALPHA-h, protein-glutamine gamma-glutamyltransferase 2, protein-glutamine-gamma-glutamyltransferase, TG(C), TG2, TGase C, TGase H, TGase-2, TGase-H, TGCGNAH, Tissue transglutaminase, transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase), Transglutaminase C, Transglutaminase H, Transglutaminase-2
Gensymboler TGM2
Värd art Mouse
Immunogen Recombinant full-length human TGM2 protein
Reningsmetod Protein A or G purified
Kvantitet 0.1 mg
Regulatorisk status RUO
Forskningsdisciplin Apoptosis, Immune System Diseases, Immunology, Signal Transduction
Primär eller sekundär Primary
Gen-ID (Entrez) 7052
Testspecificitet Recognizes a 77-85kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
Målarter Human, Monkey, Mouse, Rabbit, Rat
Innehåll och lagring Store at 4C.
Produkttyp Antibody
Form Purified
Isotyp IgG2a κ
Produktlinje Novus
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