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Invitrogen™ TRIB1 Polyclonal Antibody

Produktkod. 15694775
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Kvantitet:
100 μL
Förpackningsstorlek:
100µL
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Produktkod. Kvantitet unitSize
15694775 100 μL 100µL
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Produktkod. 15694775 Leverantör Invitrogen™ Leverantörsnummer PA550851

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Beskrivning

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total TRIB1 protein.

TRIB1 also called gprotein coupled receptor induced, skip1, gig2, c8fwATP, functions in binding protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities. Overexpression of TRIB1 in HeLa cells repressed the basal activity of the IL8 promoter by inhibiting AP1 activity. Overexpression of TRIB1 inhibited oncogenic Ras -driven AP1 activation and MEKK1-mediated AP1 activation. ERK activation was enhanced by TRIB1. Coimmunoprecipitation and yeast 2-hybrid assays showed that MEK1 interacted with both TRIB1 and TRIB3, and MKK4 interacted specifically with TRIB1. Cotransfection of MKK4 enhanced the level of TRIB1, indicating that the TRIB-MAPKK interaction stabilized TRIB1.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen TRIB1
Användningsområden Immunohistochemistry (Paraffin)
Klassificering Polyclonal
Koncentration 1.4 mg/mL
Konjugera Unconjugated
Formulering PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gen TRIB1
Genaccessionsnr. Q8K4K4, Q96RU8
Gene Alias A530090O15Rik; C8FW; Gig2; GIG-2; G-protein-coupled receptor induced protein; G-protein-coupled receptor induced protein GIG2; G-protein-coupled receptor-induced gene 2 protein; G-protein-coupled receptor-induced protein 2; phosphoprotein regulated by mitogenic pathways; SKIP1; Trb1; TRB-1; Trib1; tribbles homolog 1; tribbles homolog 1 (Drosophila); tribbles pseudokinase 1; tribbles-like protein 1
Gensymboler TRIB1
Värd art Rabbit
Immunogen Synthetic peptide corresponding to residues near the C terminal of human tribbles pseudokinase 1.
Reningsmetod Antigen Affinity Chromatography
Kvantitet 100 μL
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 10221, 211770
Målarter Human, Mouse
Innehåll och lagring -20°C
Produkttyp Antibody
Form Liquid
Isotyp IgG
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