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Tocris Bioscience™ Trichostatin A
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Produktkod. 18722564
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Kvantitet:
1 mg
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Produktkod. Kvantitet
18722564 1 mg
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Produktkod. 18722564 Leverantör Tocris Bioscience™ Leverantörsnummer 1406/1

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Beskrivning

Potent histone deacetylase inhibitor

Trichostatin A is a selective and potent inhibitor of class I and II histone deacetylases (HDAC) (Ki = 3.4 nM, IC50 values are 4.99 nM, 5.21 nM, 16.4 nM, 24.3 nM, 27.6 nM for HDAC1, 3, 6, 10 and 4, respectively). Trichostatin A induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. Trichostatin A potently inhibits a range of breast cancer and melanoma cell lines (IC50 = 29-400 nM) and induces apoptosis in prostate cancer cells. In an animal model of Huntington's disease, inhibition of HDAC by Trichostatin A rescues memory deficits and increases expression of CREB/CBP target genes in mutant mice. Activates autophagy, increases vesicular transport of BDNF (Cat. No. 2837) and is active in vivo.
TRUSTED_SUSTAINABILITY

Specifikationer

Kemiskt namn eller material Trichostatin A
CAS 58880-19-6
Kvantitet 1 mg
Molekylformel C17H22N2O3
Formel vikt 302.37
Renhet 97%
Molekylvikt (g/mol) 302.37
Produkttitel
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