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Invitrogen™ TSPO Recombinant Rabbit Monoclonal Antibody (23G2)

Produktkod. 16595831
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Kvantitet:
100 μL
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16595831 100 μL
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Produktkod. 16595831 Leverantör Invitrogen™ Leverantörsnummer MA533203

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Beskrivning

Rabbit Recombinant Monoclonal Antibody

TSPO Recombinant Monoclonal Antibody for Western Blot, ICC/IF, IHC (P), Flow, IP, ELISA

Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR is composed of three subunits, an isoquinoline binding site, a voltage-dependent anion channel and an adenine nucleotide carrier. PBR is genetically conserved from bacteria to humans and in humans is widely expressed in peripheral organs, whereas in the brain, it is sparse and located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen TSPO
Användningsområden ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Klassificering Recombinant Monoclonal
Klona 23G2
Koncentration 0.80 mg/mL
Konjugera Unconjugated
Formulering PBS with 50% glycerol, 150 mM NaCl and 0.02% sodium azide; pH 7.4
Gen Tspo
Genaccessionsnr. P30536, P50637
Gene Alias Benzodiazepin receptor (peripheral); benzodiazepine peripheral binding site; benzodiazepine receptor, peripheral; BPBS; BZRP; DBI; IBP; isoquinoline-binding protein; MBR; mDRC; mitochondrial benzodiazepine receptor; OTTHUMP00000028891; PBR; PBS; peripheral-type benzodiazepine receptor; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; translocator protein; translocator protein (18kDa); TSPO; Tspo1
Gensymboler Tspo
Värd art Rabbit
Immunogen A synthesized peptide derived from human TSPO (50-169aa).
Reningsmetod Antigen affinity chromatography, Protein G
Kvantitet 100 μL
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 12257, 706
Målarter Human, Mouse
Innehåll och lagring -20°C or -80°C if preferred
Produkttyp Antibody
Form Liquid
Isotyp IgG
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Produkttitel
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