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UBE2K Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 11834-3-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16879163

  • 1236.20 SEK / 20µL
Estimated Shipment: 02-12-2021

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Description

Description

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of ′Lys-48′-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
Specifications

Specifications

UBE2K
0.33 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P61086, P61087
E2-25K, HIP 2, HIP2, HYPG, LIG, UBE2K, Ubiquitin carrier protein, Ubiquitin protein ligase
Rabbit
IgG
20 μL
-20°C
Primary
289623, 3093, 53323
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
UBE2K
Liquid
Ube2k
UBE2K Fusion Protein Ag2415
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Rat, Mouse, Human
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