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USP5 Mouse anti-Human, Clone: 3F12C10, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66213-1-IG-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16827885

  • 1236.20 SEK / 20µL
Estimated Shipment: 02-12-2021

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Description

Description

USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in uchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the uchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Specifications

Specifications

USP5
3F12C10
Unconjugated
USP5
Liquid
USP5
USP5 Fusion Protein Ag7575
Protein A
RUO
Antibody
Monoclonal
Human
Western Blot
0.91 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P45974
Deubiquitinating enzyme 5, Isopeptidase T, ISOT, Ubiquitin thiolesterase 5, USP5
Mouse
IgG2a
20 μL
-20°C
Primary
8078
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