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USP5 Mouse anti-Human, Clone: 3F12C10, Proteintech
Mouse Monoclonal Antibody
Brand: Proteintech 66213-1-IG-20UL
Additional Details : Weight : 0.00010kg
Description
USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. It is involved in uchored Lys-48-linked polyubiquitin disassembly, and also binds linear and Lys-63 linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the uchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.Specifications
USP5 | |
Monoclonal | |
0.91 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P45974 | |
USP5 | |
USP5 Fusion Protein Ag7575 | |
20 μL | |
Primary | |
Human | |
Antibody | |
IgG2a |
Western Blot | |
3F12C10 | |
Unconjugated | |
USP5 | |
Deubiquitinating enzyme 5, Isopeptidase T, ISOT, Ubiquitin thiolesterase 5, USP5 | |
Mouse | |
Protein A | |
RUO | |
8078 | |
-20°C | |
Liquid |