missing translation for 'onlineSavingsMsg'
Learn More

TCR V beta 2, FITC, clone: B20.6, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 11-5804-82

Additional Details : Weight : 0.25000kg

 View more versions of this product

Product Code. 15268259

  • 2095.00 SEK / 100µg


Estimated Shipment date
from Supplier 27-03-2019
Add to basket

Description

Description

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Specifications

Specifications

TCR V beta 2
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
TCR Vb2; TCRV beta-2; Vbeta 2; Vbeta2; Vb 2; Vb2
IgG2a, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
Mouse
Flow Cytometry
B20.6
FITC
Liquid
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Videos

For Research Use Only.