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VEGF Receptor 3 Rat anti-Mouse, Clone: AFL4, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-5988-81

Additional Details : Weight : 0.01000kg

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Product Code. 15207677

  • 714.00 SEK / 50µg


Estimated Shipment
06-11-2020
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Description

Description

Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.
Specifications

Specifications

VEGF Receptor 3
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P35917
FLT41, PCL, FLT4
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Neutralization, Western Blot
AFL4
Unconjugated
Flt4
Liquid
Flt4
IgG2a, kappa
50 μg
4° C
Primary
14257
Videos
SDS
Documents

For Research Use Only.