VEGF Receptor 3 Rat anti-Mouse, Clone: AFL4, eBioscience™
Rat Monoclonal Antibody
Brand: Affymetrix eBioscience 14-5988-81
Additional Details : Weight : 0.01000kg
DescriptionAggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.
|VEGF Receptor 3|
|PBS with 0.09% sodium azide; pH 7.2|
|FLT41, PCL, FLT4|
|Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunoprecipitation, Neutralization, Western Blot|
For Research Use Only.