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  6. Invitrogen™ CD170 (Siglec F) Monoclonal Antibody (1RNM44N), Brilliant Violet™ 711, eBioscience™, Invitrogen™

Invitrogen™ CD170 (Siglec F) Monoclonal Antibody (1RNM44N), Brilliant Violet™ 711, eBioscience™, Invitrogen™

Produktkod. 17867140
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17867140 25 μg
17877140 100 μg
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Produktkod. 17867140 Leverantör Invitrogen™ Leverantörsnummer 407170280

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Beskrivning

Rat Monoclonal Antibody

This 1RNM44N mAb recognizes mouse CD170, also known as Siglec F. Siglec F is a cell surface lectin belonging to the Ig superfamily that binds glycoconjugates containing sialic acids that are commonly found on various cell types. The cytoplasmic domain of Siglec F contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) that initiates intracellular signaling upon ligand binding. Siglec F is expressed mostly on eosinophils and alveolar macrophages and lower levels of this receptor have also been reported on immature myelomonocytic cells. Mouse Siglec F is a functional ortholog of human Siglec 8, however, unlike human Siglec 8, mouse Siglec F is not expressed on mast cells. This 1RNM44N antibody will recognize a formaldehyde-fixed epitope. Applications Reported: This 1RNM44N antibody has been reported for use in flow cytometric analysis. Applications Tested: This 1RNM44N antibody has been tested by flow cytometric analysis of mouse thioglycolate-elicited peritoneal exudate cells. BV 711 is a tandem dye that emits at 713nm and is intended for use on cytometers equipped with a violet (405nm) laser. Excitation: 407nm; Emission: 713nm; Laser: Violet Laser. BV is a trademark or registered trademark of Becton, Dickinson and Company or its affiliates, and is used under license. Powered by Sirigen.

SIGLEC5 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. This protein binds equally to alpha2,3-linked and alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. This molecule is expressed by monocytic/myeloid lineage cells. SIGLEC5 is found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. It is expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.
TRUSTED_SUSTAINABILITY

Specifikationer

Antigen CD170 (Siglec F)
Användningsområden Flow Cytometry
Klassificering Monoclonal
Klona 1RNM44N
Koncentration 0.2 mg/mL
Konjugera Brilliant Violet 711
Formulering PBS with BSA and 0.09% sodium azide; pH 7.2
Gen Siglecf
Genaccessionsnr. Q920G3
Gene Alias CD170; CD33 antigen-like 2; CD33L2; mSiglec-F; OB-binding protein 2; OBBP2; OB-BP2; Obesity-binding protein 2; sialic acid binding Ig like lectin 5; sialic acid binding Ig-like lectin 5; sialic acid binding Ig-like lectin F; sialic acid-binding Ig-like lectin 5; Sialic acid-binding Ig-like lectin F; sialic acid-binding immunoglobulin-like lectin 5; sialic acid-binding lectin Siglec-F; Siglec; SIGLEC5; siglec-5; Siglecf; Siglec-F
Gensymboler Siglecf
Värd art Rat
Reningsmetod Affinity chromatography
Kvantitet 25 μg
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 233186
Målarter Mouse
Innehåll och lagring 4°C, store in dark, DO NOT FREEZE!
Produkttyp Antibody
Form Liquid
Isotyp IgG2a κ
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