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Vinculin Mouse anti-Human, Mouse, Rat, eFluor® 570, Clone: 7F9, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 41-9777-82

Additional Details : Weight : 0.09500kg

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Product Code. 15558976

  • 3245.00 SEK / 100µg


In stock, ready to ship: 1
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Description

Description

Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.
Specifications

Specifications

vinculin
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
Q64727, P85972, P18206
RP11-178G16.3, CMD1W, MVCL
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
7F9
eFluor™ 570
VCL
Liquid
Vcl
IgG1, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
22330, 305679, 7414
Videos
SDS
Documents

For Research Use Only.