VRK3 Polyclonal Antibody, Invitrogen™

Description

Immunogen sequence: CPYCGNSLPVE EHVGSQTFVN PHVSSFQGSK RGLNSSFETS PKKVKWSSTV TSPRLSLFSD GDSSESEDTL SS Highest antigen sequence identity to the following orthologs - mouse 68%, rat 73%.

This gene encodes a member of the vaccinia-related kinase family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms.