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Tocris Bioscience™ VU 6005649
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Produktkod. 18709736
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Produktkod. Kvantitet
18709736 10 mg
18757836 50 mg
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Produktkod. 18709736 Leverantör Tocris Bioscience™ Leverantörsnummer 6893/10

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Description

Positive allosteric modulators of mGlu7 and mGlu8 receptors. Also NK1 antagonist.

VU 6005649 is a positive allosteric modulator of mGlu7 and mGlu8 receptors (EC50 = 0.65 μM and 2.6 μM for mGlu7 and mGlu8, respectively). Displays >3.8 fold selectivity for mGlu7 and mGlu8 over other mGlu receptors (EC50 >10 μM for mGlu1,2,3,4,5,6). Also NK1 receptor antagonist (Ki= 650 nM, IC50 = 3.4 μM). Brain penetrant.
TRUSTED_SUSTAINABILITY

Specifications

Kemiskt namn eller material 3-(2,3-Difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
CAS 2137047-43-7
Kvantitet 10 mg
Molekylformel C16H12F5N3O
Renhet 98%
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