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STEMCELL Technologies XAV939

Produktkod. 17180102
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Produktkod. 17180102 Leverantör STEMCELL Technologies Leverantörsnummer 72674

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Beskrivning

WNT pathway inhibitor; Inhibits TNKS1 and TNKS2

  • XAV939 is a potent, small molecule inhibitor of tankyrase (TNKS) 1 and 2 (IC50 = 11 and 4 nM, respectively) (Huang et al.) By inhibiting TNKS activity, XAV939 increases the protein levels of the axin-GSK3β complex and promotes the degradation of β-catenin in SW480 cells (Huang et al.), thereby inhibiting WNT pathway downstream actions
  • Induces cardiomyogenesis in mesoderm progenitor cells derived from mouse embryonic stem cells (Wang et al.)
  • In combination with the SMAD inhibitors LDN193189 and SB431542, promotes induction of forebrain fates in human pluripotent stem cell lines (Maroof et al.)
  • Inhibits colony formation of APC-deficient, β-catenin-dependent DLD-1 colorectal cancer cells (Huang et al.)

Specifikationer

CAS 284028-89-3
Kvantitet 10 mg
Molekylformel C14H11F3N2OS
Renhet ≥98%
Produkttitel
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