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Invitrogen™ ZO-1 Monoclonal Antibody (ZO1-1A12)
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Produktkod. 10129012
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Kvantitet:
100 μg
Förpackningsstorlek:
Varje
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10129012 100 μg Varje
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For Research Use Only. All usage must comply with product instructions.
Produktkod. 10129012 Leverantör Invitrogen™ Leverantörsnummer 339100

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3412.40 SEK valid until 2026-04-10
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For Research Use Only. All usage must comply with product instructions.

Beskrivning

Mouse Monoclonal Antibody

33-9100 has been successfully used in ELISA, Immunofluorescence and Western Blot analysis of ZO-1.

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
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Specifikationer

Antigen ZO-1
Användningsområden ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Multiplex Immunohistochemistry
Klassificering Monoclonal
Klona ZO1-1A12
Koncentration 0.5 mg/mL
Konjugera Unconjugated
Formulering PBS with 0.1% sodium azide; pH 7.4
Gen TJP1
Genaccessionsnr. O97758, P39447, Q07157
Gene Alias DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Gensymboler TJP1
Värd art Mouse
Immunogen Human recombinant ZO-1 fusion protein encompassing amino acids 334-634.
Reningsmetod Affinity chromatography
Kvantitet 100 μg
Regulatorisk status RUO
Primär eller sekundär Primary
Gen-ID (Entrez) 21872, 403752, 7082, 720550
Målarter Human, Mouse, Canine, Monkey, Rhesus Macaque
Innehåll och lagring -20°C
Produkttyp Antibody
Form Liquid
Isotyp IgG1
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