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Invitrogen™ ZO-1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ 402200

Produktkod. 10017242

  • 5150.00 SEK / 100µg

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For Research Use Only. All usage must comply with product instructions.

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Beskrivning

Beskrivning

40-2200 was used successfully in the immunofluorescence analysis of Zo-1 in MDCK cells.

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
TRUSTED_SUSTAINABILITY
Specifikationer

Specifikationer

ZO-1
Polyclonal
Unconjugated
TJP1
DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Rabbit
Antigen affinity chromatography
RUO
21872, 292994, 403752, 7082
-20°C
Liquid
Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
0.25 mg/mL
PBS with 0.1% sodium azide; pH 7.4
O97758, P39447, Q07157
TJP1
Synthetic peptide in the middle region of the ZO-1 protein.
100 μg
Primary
Canine, Human, Mouse, Rat
Antibody
IgG
Produktförslag

Produktförslag

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