This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Colorectal cancer suppressor; colorectal tumor suppressor; deleted in colorectal cancer protein; deleted in colorectal carcinoma; Immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1; Netrin receptor DCC; Netrin receptor DCC Colorectal cancer suppressor Immunoglobulin superfamily DCC subclass member 1 Tumor suppressor protein DCC DCC IGDCC1; putative colorectal tumor suppressor; Tumor suppressor protein DCC
Cat # 15904715
100 µg
Cat # 15752182
100 µL
Cat # 15718882
25 ug
Cat # 17139333
100 µL
Cat # 16118410
100 µL
Cat # 15563922
100 µg
Cat # 15604875
100 µL
Cat # 15739842
25 ug
Cat # 16848884
150 µL
Cat # 16858884
20 µL
Cat # 13429484
100 ug
Cat # 16372815
100 µL
Cat # 15737684
25 ug
Cat # 15558442
100 µg
Cat # 13470265
100 ug
Cat # 16162320
100 ug
Cat # 13411126
100 ug
Cat # 13482185
50 ug
Cat # 17237863
100 µL
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