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Pds1 Antibodies

Pds1 is an anaphase inhibitor and plays important role in DNA damage and spindle check point pathways. Pds1 inhibits sister chromatid separation by binding and inhibiting Esp1, cystein protease that causes cleavage of the cohesin Scc1 that binds the sister chromatids together. Pds1 is responsible for targeting of Esp1 to nucleus and its binding to the spindle. Degradation of Pds1 occurs shortly before anaphase, which liberates Esp1 and is a prerequisite for anaphase entry. Pds1 is targeted for degradation by ubiquitination mediated by cyclosome/anaphase-promoting complex (APC) functioning as a ubiquitin ligase. In response to DNA ...


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Pds1 Mouse anti-Human, Mouse, Clone: DCS-280, Invitrogen™ Pds1 Mouse anti-Human, Mouse, Clone: DCS-280, Invitrogen™
VALIDATION
TARGET Many
DETAILS Mouse Monoclonal
APPLICATION IHC (P) WB
PRICE 

Cat # 11354603

500 µL

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