The expression pattern of the Prox1 homeo box gene suggests that it has a role in a variety of embryonic tissues, including lens. Analysis of mRNA reveals that Prox mRNA is present in many different human tissues and that lens demonstrated the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate ...
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150 µL
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100 µg
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0.1 ml
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400 µL
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100 µL
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400 uL
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400 uL
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100 ug
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0.1 ml
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400 µL
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400 uL
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100 µg
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0.025 ml
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100 µg
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100 µg
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100 µL
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100 µL
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25 ug
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50 ug
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0.1 ml
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100 µL
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100 µg
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150 µL
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20 µL
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20 µL
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