CAS RN 1168091-68-6

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GDC-0623, MedChemExpress

MedChemExpress GDC-0623 (RG 7421) is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM).

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Specifications

Molecular Weight (g/mol)	456.21
Color	Yellow
Physical Form	Solid
Chemical Name or Material	GDC-0623
Grade	Research
SMILES	FC(C=C(I)C=C1)=C1NC2=C(C(NOCCO)=O)C=CC3=CN=CN23
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	95.0%
CAS	1168091-68-6
Solubility Information	DMSO : 50 mg/mL (109.60 mM; Need ultrasonic)
Synonym	RG 7421 MEK inhibitor 1
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₆H₁₄FIN₄O₃
Formula Weight	456.21

CAS RN 1168091-68-6

CAS RN 1168091-68-6

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