CAS RN 1263094-00-3
IUPAC Namn:
7-chloro-4-oxo-1,4-dihydroquinoline-2-carboxylic acid sodium
Synonymer:
7-chloro-kyurenic acid sodium
Molekylvikt (g/mol):
246.6
Molekylär sammansättning:
C10H6ClNNaO3
InChi Key:
MNYKNNXDFLKIJJ-UHFFFAOYSA-N
SMILES:
[Na].OC(=O)C1=CC(=O)C2=CC=C(Cl)C=C2N1
1
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2
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2
Resultat
1
7-Chlorokynurenic acid sodium salt, MedChemExpress
MedChemExpress 7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid sodium salt is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid sodium salt has potent antinociceptive actions after neuraxial delivery.