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CAS RN 1561178-17-3

IUPAC Namn: 3-(3-{[(5-{4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-3,4-dihydroxyoxolan-2-yl)methyl](propan-2-yl)amino}propyl)-1-(4-tert-butylphenyl)urea
Synonymer: 3-(3-{[(5-{4-amino-5-bromopyrrolo[2,3-d]pyrimidin-7-yl}-3,4-dihydroxyoxolan-2-yl)methyl](isopropyl)amino}propyl)-1-(4-tert-butylphenyl)urea
Molekylvikt (g/mol): 618.58
Molekylär sammansättning: C28H40BrN7O4
InChi Key: IQCKJUKAQJINMK-UHFFFAOYNA-N
SMILES: CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC1OC(C(O)C1O)N1C=C(Br)C2=C(N)N=CN=C12
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1 – 3 av 3 Resultat
1

SGC-0946, TRC

CAS: 1561178-17-3 Molekylformel: C28H40BrN7O4 Molekylvikt (g/mol): 618.57 Synonym: SGC-0946,5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine IUPAC-namn: 1-[3-[[(2R,3S,4R,5R)-5-(4-amino-5-bromopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea LEDER: CC(C)N(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n3cc(Br)c4c(N)ncnc34

Molekylformel C28H40BrN7O4
IUPAC-namn 1-[3-[[(2R,3S,4R,5R)-5-(4-amino-5-bromopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea
CAS 1561178-17-3
LEDER CC(C)N(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n3cc(Br)c4c(N)ncnc34
Molekylvikt (g/mol) 618.57
Synonym SGC-0946,5-Bromo-7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
2

Tocris Bioscience™ SGC 0946
GREENER_CHOICE

Highly potent and selective DOT1L inhibitor; cell permeable

3

SGC0946, MedChemExpress

MedChemExpress SGC0946 is a selective DOT1LH3K79 methyltransferase) inhibitor, with an IC50 of 0.3 nM. SGC0946 results in G1 arrest, inhibits potential of cell self-renewal and metastatic, also induces cell differentiation. SGC0946 can be used in studies of leukemia and solid tumors and also serve as a probe to further investigate the cellular mechanism of DOT1L in both normal and diseased cells.

ENCOMPASS_PREFERRED
Molekylformel C28H40BrN7O4
Rekommenderad förvaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Formel vikt 618.57
Hållbarhet Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Hälsofara 1 H301
Löslighetsinformation DMSO : 50 mg/mL (80.83 mM; Need ultrasonic)
Anteckningar om renhetsgrad Research
Fysisk form Solid
Kvalitet Research
Färg Light Nude
CAS 1561178-17-3
LEDER NC1=NC=NC2=C1C(Br)=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CN(CCCNC(NC4=CC=C(C(C)(C)C)C=C4)=O)C(C)C)O3
Molekylvikt (g/mol) 618.57
Kemiskt namn eller material SGC0946
Procent renhet 98.0%
För användning med (applikation) Cancer-programmed cell death