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AATF Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 10282-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16886563

  • 3313.85 SEK / 150µL
Estimated Shipment: 08-12-2021

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Description

Description

AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases. AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways. Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the beta-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer′s disease (AD), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.
Specifications

Specifications

AATF
0.39 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q9JKX4, Q9NY61, Q9QYW0
AATF, CHE 1, CHE1, DED, Protein AATF, Rb binding protein Che 1, Traube
Rabbit
IgG
150 μL
-20°C
Primary
114512, 26574, 56321
Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
AATF
Liquid
AATF
AATF Fusion Protein Ag0195
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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