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AATF Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 10282-1-AP-150UL
Additional Details : Weight : 0.00010kg
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DescriptionAATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases. AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways. Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the beta-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer′s disease (AD), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.
|AATF, CHE 1, CHE1, DED, Protein AATF, Rb binding protein Che 1, Traube|
|Antigen Affinity Chromatography|
|114512, 26574, 56321|
|Western Blot, Immunofluorescence, Immunocytochemistry|
|PBS with 50% glycerol and 0.1% sodium azide; pH 7.3|
|Q9JKX4, Q9NY61, Q9QYW0|
|AATF Fusion Protein Ag0195|
|Rat, Mouse, Human|