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Alpha E catenin Mouse anti-Human, Mouse, Clone: 2B7B8, Proteintech

Mouse Monoclonal Antibody

Brand:  Proteintech 66221-1-IG-20UL

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Product Code. 16887895

  • 1645.54 SEK / 20µL

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Description

Description

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
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Product Title
Alpha E catenin Mouse anti-Human, Mouse, Clone: 2B7B8, Proteintech > 20 μL; Unconjugated

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