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Alpha E catenin Mouse anti-Human, Mouse, Clone: 2B7B8, Proteintech
Mouse Monoclonal Antibody
Brand: Proteintech 66221-1-IG-20UL
Additional Details : Weight : 0.00010kg
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DescriptionAssociates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
|Alpha E catenin|
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|Alpha E catenin Fusion Protein Ag23603|
|Immunohistochemistry (Paraffin), Western Blot|
|Alpha E catenin, Cadherin associated protein, CAP102, Catenin alpha 1, CTNNA1|