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TCR V delta 2 Mouse anti-Human, Clone: 15D, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen TCR1732

Additional Details : Weight : 1.81440kg

Product Code. 11888831

  • 3670.00 SEK / 200µg


In stock, ready to ship: 3
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Description

Description

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Specifications

Specifications

TCR V delta 2
Monoclonal
0.15 mg/mL
PBS with 0.5% BSA and 0.1% sodium azide
Liquid
Mouse
IgG1
200 μg
-20°C
Primary
6964
Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation, T-Cell Activation, Western Blot
15D
Unconjugated
TRD
TRD
Human TCR V delta 2
Protein A
RUO
Antibody
Monoclonal
Human
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