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Tocris Bioscience™ ASP 3026
Potent anaplastic lymphoma kinase (ALK) inhibitor; also potent ACK inhibitor
1580.00 SEK - 6175.00 SEK
Specifications
| Chemical Name or Material | N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine |
|---|---|
| CAS | 1097917-15-1 |
| Target | ALK Inhibitors |
| Molecular Formula | C29H40N8O3S |
| Formula Weight | 580.74 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18701698
|
Tocris Bioscience™
|
10 mg |
1580.00 SEK
10mg |
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|
18730518
|
Tocris Bioscience™
|
50 mg |
6175.00 SEK
50mg |
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Description
Potent anaplastic lymphoma kinase (ALK) inhibitor (IC50 = 3.5 nM). Also inhibits Ack and ROS1 activity (IC50 values are 5.8 and 8.9 nM respectively). Attenuates proliferation, and induces apoptosis of NPM-ALK+ T cell anaplastic large-cell lymphoma (ALCL) cells in vitro. Suppresses tumor growth of NPM-ALK+ ALCL cell xenografts in mice. Causes tumor shrinkage in hEML4-ALK transgenic mice. Orally available.Specifications
| N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine | |
| ALK Inhibitors | |
| 580.74 |
| 1097917-15-1 | |
| C29H40N8O3S | |
| >99% |
Safety and Handling
Recommended Storage : Store at -20°C
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Product Title
Tocris Bioscience™ ASP 3026