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ATG12 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 11264-1-AP-20UL

Additional Details : Weight : 0.00010kg

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Product Code. 16828223

  • 1236.20 SEK / 20µL
Estimated Shipment: 07-12-2021

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Description

Description

ATG12, a member of the autophagy protein family, forms a conjugate with ATG5 this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. ATG12 has also been shown to interact with ATG10 in human embryonic kidney cells in the presence of ATG7. At least two isoforms of ATG12 are known to exist. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1.
Specifications

Specifications

ATG12
0.19 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O94817, Q2TBJ5, Q9CQY1
APG12, APG12 like, APG12L, ATG12, Autophagy related protein 12, FBR93, HAPG12, Ubiquitin like protein ATG12
Rabbit
IgG
20 μL
-20°C
Primary
361321, 67526, 9140
Immunofluorescence, Western Blot, Immunohistochemistry (Paraffin), Immunocytochemistry
Unconjugated
ATG12
Liquid
Atg12
ATG12 Fusion Protein Ag1791
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Rat, Mouse
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