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ATR Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 19787-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16889264

  • 4721.67 SEK / 150µL
Estimated Shipment: 03-04-2024
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Description

Description

The antibody can recognize all the isoform of ATR.

The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.
Specifications

Specifications

ATR
Polyclonal
Unconjugated
ATR
ATR, FRAP related protein 1, FRP1, MEC1, SCKL, SCKL1
Rabbit
Antigen Affinity Chromatography
RUO
245000, 545, 685055
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.28 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q13535, Q9JKK8
ATR
Peptide
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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