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AXIN2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 20540-1-AP-150UL

Additional Details : Weight : 0.00010kg

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Product Code. 16890085

  • 3665.00 SEK / 150µL
Estimated Shipment: 31-03-2023
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Description

Description

20540-1-AP is a rabbit polyclonal antibody raised against a 34 amino acid N-terminal of human AXIN2. Observed MW of AXIN2 is from 93-100 kDa.

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of maligcies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Specifications

Specifications

AXIN2
Polyclonal
Unconjugated
AXIN2
AXIL, axin 2, Axin like protein, AXIN2, Axis inhibition protein 2, Conductin
Rabbit
Antigen Affinity Chromatography
RUO
12006, 29134, 8313
-20°C
Liquid
Western Blot
0.47 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
O70240, O88566, Q9Y2T1
Axin2
AXIN2 Fusion Protein Ag14574
150 μL
Primary
Rat, Mouse, Human
Antibody
IgG
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