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AXIN2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 20540-1-AP-150UL
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Description
20540-1-AP is a rabbit polyclonal antibody raised against a 34 amino acid N-terminal of human AXIN2. Observed MW of AXIN2 is from 93-100 kDa.
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of maligcies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.Specifications
| AXIN2 | |
| Polyclonal | |
| Unconjugated | |
| AXIN2 | |
| AXIL, axin 2, Axin like protein, AXIN2, Axis inhibition protein 2, Conductin | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 12006, 29134, 8313 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 0.47 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| O70240, O88566, Q9Y2T1 | |
| Axin2 | |
| AXIN2 Fusion Protein Ag14574 | |
| 150 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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Product Title
AXIN2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech > 150 μL; Unconjugated
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