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BAF53B Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 27215-1-AP-20UL

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Product Code. 16885485

  • 1645.54 SEK / 20µL

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Description

Description

Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth.
Specifications

Specifications

BAF53B
Polyclonal
Unconjugated
ACTL6B
actin like 6B, Actin like protein 6B, Actin related protein Baf53b, ACTL6, ACTL6B, ArpNalpha, BAF53B, BRG1 associated factor 53B
Rabbit
Antigen Affinity Chromatography
RUO
288563, 51412, 83766
-20°C
Liquid
Western Blot
0.3 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
O94805, P86173, Q99MR0
Actl6b
BAF53B Fusion Protein Ag25745
20 μL
Primary
Rat, Mouse, Human
Antibody
IgG
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BAF53B Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech > 20 μL; Unconjugated

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