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Calnexin Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1656.73 SEK - 4721.67 SEK

Specifications

Antigen Calnexin
Concentration 0.39 mg/mL
Applications Western Blot, Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16826813
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Proteintech
10427-2-AP-20UL
20 μL
1656.73 SEK
20µL
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Estimated Shipment: 03-04-2024
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16816813
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Proteintech
10427-2-AP-150UL
150 μL
4721.67 SEK
150µL
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Estimated Shipment: 03-04-2024
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Description

Description

Calnexin, also referred to as IP90, p88 and p90, is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER). Many resident ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multisubunit proteins. Studies indicate that calnexin associates with the major histocompatibility complex (MHC) class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes. It has been shown that calnexin is a chaperone that retains incompletely or improperly folded proteins in the ER. The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble ER resident proteins such as GRP78 and GRP94 and protein disulfide isomerase. Integral membrane ER resident proteins, like calnexin, often lack this KDEL sequence but contain positively charged cytosolic residues that ensure ER retention. Calnexin contains a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids).
Specifications

Specifications

Calnexin
Western Blot, Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunocytochemistry
Unconjugated
Rabbit
Rat, Human, Mouse
P27824, P35564, P35565
12330, 29144, 821
Calnexin Fusion Protein Ag0697
Primary
-20°C
CANX
0.39 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
calnexin, CANX
Canx
IgG
Antigen Affinity Chromatography
Antibody
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SDS
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Documents

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