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CD117 (c-Kit) Mouse anti-Human, APC, Clone: 104D2, eBioscience™
Mouse Monoclonal Antibody
1284.00 SEK - 2710.00 SEK
Specifications
| Antigen | CD117 (c-Kit) |
|---|---|
| Clone | 104D2 |
| Target Species | Human |
| Conjugate | APC |
| Isotype | IgG1, kappa |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15577986
|
Affymetrix eBioscience
17-1178-41 |
25 Tests |
1284.00 SEK
25 tests |
23-02-2021 |
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|
15587986
|
Affymetrix eBioscience
17-1178-42 |
100 Tests |
2710.00 SEK
100 tests |
|
|||||
Description
c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation of the Ras-Raf-ERK1&2 signaling pathway.Specifications
| CD117 (c-Kit) | |
| Human | |
| IgG1, kappa | |
| Monoclonal | |
| Liquid | |
| Antibody | |
| 4° C, store in dark, DO NOT FREEZE! |
| 104D2 | |
| APC | |
| Flow Cytometry | |
| Primary | |
| Monoclonal | |
| PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2 | |
| RUO |
For Research Use Only.