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CD117 (c-Kit) Mouse anti-Human, APC, Clone: 104D2, eBioscience™

Mouse Monoclonal Antibody

1284.00 SEK - 2710.00 SEK

Specifications

Antigen CD117 (c-Kit)
Clone 104D2
Target Species Human
Conjugate APC
Isotype IgG1, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15577986
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Affymetrix eBioscience
17-1178-41
25 Tests
1284.00 SEK
25 tests
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Estimated Shipment
23-02-2021
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15587986
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Affymetrix eBioscience
17-1178-42
100 Tests
2710.00 SEK
100 tests
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In stock, ready to ship: 1
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Description

Description

c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation of the Ras-Raf-ERK1&2 signaling pathway.
Specifications

Specifications

CD117 (c-Kit)
Human
IgG1, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
104D2
APC
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.