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CD117 (c-Kit) Mouse anti-Human, Clone: YB5.B8, eBioscience™
Mouse Monoclonal Antibody
Brand: Affymetrix eBioscience 14-1179-80
Additional Details : Weight : 0.01000kg
Description
c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation of the Ras-Raf-ERK1&2 signaling pathway.Specifications
| CD117 (c-kit) | |
| Monoclonal | |
| 0.5 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.2 | |
| P10721 | |
| C-Kit, CD117, PBT, SCFR, mast/stem cell growth factor receptor Kit, p145 c-kit, piebald trait protein, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, soluble KIT variant 1, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, ckit | |
| Mouse | |
| Affinity chromatography | |
| RUO | |
| Antibody | |
| Monoclonal | |
| Human |
| Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation | |
| YB5.B8 | |
| Unconjugated | |
| KIT | |
| Liquid | |
| KIT | |
| IgG1, kappa | |
| 25 μg | |
| 4° C | |
| Primary | |
| 3815 |
For Research Use Only.