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CD2 Rat anti-Mouse, FITC, Clone: RM2-5, eBioscience™

Rat Monoclonal Antibody

355.00 SEK - 2500.00 SEK

Specifications

Antigen CD2
Clone RM2-5
Target Species Mouse
Conjugate FITC
Isotype IgG2b, lambda
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Products 4
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15287969
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Affymetrix eBioscience
11-0021-63
10 μg
355.00 SEK
10µg
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Estimated Shipment
14-01-2021
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15297969
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Affymetrix eBioscience
11-0021-81
50μg
718.00 SEK
50µg
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Estimated Shipment
14-01-2021
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15207979
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Affymetrix eBioscience
11-0021-82
100 μg
1342.00 SEK
100µg
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Estimated Shipment
11-12-2020
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15217979
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Affymetrix eBioscience
11-0021-85
500 μg
2500.00 SEK
500µg
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Estimated Shipment
14-01-2021
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Description

Description

CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. CD2 is one of the earliest T-cell markers, being present on more than 95% of thymocytes and it is also found on some natural killer cells, but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it. The interaction betwee CD2 and CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to the absence of the thymus.
Specifications

Specifications

CD2
Mouse
IgG2b, lambda
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
RM2-5
FITC
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.