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CD254 (RANK Ligand) Rat anti-Mouse, PE, Clone: IK22/5, eBioscience™

Rat Monoclonal Antibody

1342.00 SEK - 1714.00 SEK

Specifications

Antigen CD254 (RANK Ligand)
Clone IK22/5
Target Species Mouse
Conjugate PE
Isotype IgG2a, kappa
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15208939
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Affymetrix eBioscience
12-5952-81
50 μg
1342.00 SEK
50µg
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Estimated Shipment
11-01-2021
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15218939
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Affymetrix eBioscience
12-5952-82
100 μg
1714.00 SEK
100µg
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Estimated Shipment
11-01-2021
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Description

Description

Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregcy. Two alternatively spliced transcript variants have been found.
Specifications

Specifications

CD254 (RANK Ligand)
Mouse
IgG2a, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
IK22/5
PE
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.