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CD325 (N-Cadherin) Mouse anti-Human, Clone: 8C11, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-3259-82

Additional Details : Weight : 0.01000kg

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Product Code. 15217347

  • 1072.00 SEK / 100µg


EU Stock 1
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Description

Description

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. N-cadherin is a 140 kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin′s function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.
Specifications

Specifications

CD325 (N-cadherin)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P19022
Cadherin-2, Neural-cadherin, CDw325 antigen, CD325, CDHN, NCAD, Cadherin-N
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
8C11
Unconjugated
CDH2
Liquid
CDH2
IgG1, kappa
100 μg
4° C
Primary
1000
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For Research Use Only.