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CD86 (B7-2) Rat anti-Mouse, PE, Clone: GL1, eBioscience™

Rat Monoclonal Antibody

900.00 SEK - 4390.00 SEK

Specifications

Antigen CD86 (B7-2)
Clone GL1
Target Species Mouse
Conjugate PE
Isotype IgG2a, kappa
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Products 4
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15218609
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Affymetrix eBioscience
12-0862-81
50 μg
900.00 SEK
50µg
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Estimated Shipment
08-12-2020
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15228609
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Affymetrix eBioscience
12-0862-82
100 μg
1718.00 SEK
100µg
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In stock, ready to ship: 2
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15238609
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Affymetrix eBioscience
12-0862-83
200 μg
2505.00 SEK
200µg
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Estimated Shipment
07-01-2021
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15248609
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Affymetrix eBioscience
12-0862-85
500 μg
4390.00 SEK
500µg
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Estimated Shipment
07-01-2021
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Description

Description

Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. CD86 is one of two ligands (the other CD80) for CTLA4 and CD28. CD86 acts as costimulatory molecule in eliciting T-cell help during antigen presentation. Antigen presentation in the absence of sufficient co-stimulation involving CD86/CD80 can induce tolerance. CD80 appears to play a role distinct from CD80 in T helper cell differentiation. CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. The CD86 protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms of CD86. Additional transcript variants have been described for CD86, but their full-length sequences have not been determined. Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
Specifications

Specifications

CD86 (B7-2)
Mouse
IgG2a, kappa
Monoclonal
Liquid
Antibody
4° C, store in dark, DO NOT FREEZE!
GL1
PE
Flow Cytometry
Primary
Monoclonal
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.